CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells.
Conventionally, trailmaster challenger 200x signaling through BCR initiates sequence of events necessary for activation and differentiation of B cells.We report an alternative approach, independent of BCR, for stimulating resting B (RB) cells, by involving TLR-2 and CD40--molecules crucial for innate and adaptive immunity.CD40 triggering of TLR-2 s